徠卡Bcl-2 Oncoprotein蛋白抗體
Clone bcl-2/100/D5
7 mL BOND ready-to-use PA0117 P (HIER)
Antigen Background
Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2
is an integral inner mitochondrial membrane protein of 25 kD ａnd has a wide
tissue distribution. It is considered to act as an inhibitor of apoptosis. For this
reason, bcl-2 expression is inhibited in germinal centers where apoptosis
forms part of the B cell production pathway. In 90 percent of follicular
lymphomas a translocation occurs which juxtaposes the bcl-2 gene at 18q21,
to an immunoglobulin gene. This t(14;18) translocation can deregulate gene
expression ａnd bcl-2 over-expression can be demonstrated immunohistochemically in the vast majority of follicular lymphomas.
Also available as a liquid concentrate, refer to page 98
Human diffuse large B cell lymphoma: immunohistochemical staining for Bcl-6 using PA0204.
Note nuclear staining of neoplastic cells. Paraffin section.
更新時間：2024/11/12 13:40:42
經營許可證號：滬寶食藥監械經營許20220040號
標簽：蛋白抗體 Bcl-2蛋白 Leica克隆抗體
技術支持：阿儀網， (滬)-非經營性-2022-0060總訪問量：4527289
