徠卡抗體Anaplastic Lymphoma Kinase
Clone 5A4
7 mL BOND ready-to-use PA0306 P (HIER)
Antigen Background
Anaplastic large cell lymphoma (ALCL) is usually composed of large
pleomorphic cells which are reported to express CD30 antigen ａnd the
epithelial membrane antigen (EMA). These tumor cells tend to occur in
younger individuals ａnd may be associated with cutaneous ａnd extranodal
involvement. A proportion of these cases contain a chromosomal
translocation t(2;5) (p23; q35). This results in a hybrid gene encoding part of
the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the
anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large
cell lymphomas account for approximately 25 percent of all non-Hodgkin＇s
lymphomas in children ａnd young adults, of which one third carries the NPMALK gene translocation.
Human anaplastic lymphoma: immunohistochemical staining for anaplastic lymphoma
kinase (p80) using NCL-ALK. Note cytoplasmic staining of large pleomorphic cells. Paraffin
section.
更新時間：2024/11/12 13:40:42
經營許可證號：滬寶食藥監械經營許20220040號
標簽：ALCL 克隆抗體 Anaplastic Lymphoma Kinase
技術支持：阿儀網， (滬)-非經營性-2022-0060總訪問量：4527289
